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Exposure assessmentFor all cases and controls, we obtained information on all drugs prescribed between cohort entry and the index date, including diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and NSAIDs. We defined a double therapy combination as the concurrent use of either diuretics, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers with NSAIDs. We defined a triple therapy combination as the concurrent use of diuretics and angiotensin converting enzyme inhibitors or angiotensin receptor blockers, along with NSAIDs. To be considered a double or triple therapy combination, the drugs of interest had to have https://www.monclervancouver.nu been prescribed on the same day or, alternatively, their specified durations of use had to overlap each other for at least one day during follow up. We calculated this by using the number of prescribed tablets combined with dosing instructions and daily dose. We divided the number https://www.monclervancouver.nu of https://en.wikipedia.org/wiki/Moncler prescribed units by the daily dose to obtain the expected duration of drug use. For the antihypertensive drugs, we defined continuous use as when the duration of one prescription overlapped the date of the next prescription, allowing moncler coat red
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determined by both the pharmacokinetics and prescribing patterns of these drugs in general practice28). For NSAIDs, continuous use was similarly defined, but the grace period consisted of the half life of the drug. In the special situation in which patients were prescribed more than one NSAID, we used the one with the longest half life to determine the overlap with the antihypertensive drugs.